| Alternative Name: | PNP14, Phosphoneuroprotein 14, SNCB |
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| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to aa 97-111 of human β-synuclein. |
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| UniProt ID: | Q16143 |
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| Species reactivity: | Human, Mouse, Rat |
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| Applications: | IHC, WB |
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| Blocking Peptide: | For Blocking peptide see Prod. No. BML-SP9345. |
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| Formulation: | Liquid. In PBS, pH 7.4 containing 0.01M sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | β-synuclein (phosphoneuroprotein 14; SNCB) is abundant in the central nervous system and is localised at nerve endings but not in synaptic vesicles. β-synuclein is associated with novel axonal pathology in Parkinson’s disease and in dementia with Lewy bodies. Unlike a-synuclein in which two mutations associated with familial Parkinsons disease have been found, no pathogenic mutations have been identified in β-synuclein. β-synuclein expression in the testis changes with developmental stage, being increased markedly when spermatogonia undergo two rounds of meiosis, suggesting a role for β-synuclein in meiosis. |
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