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ProductDetails
SynonymsMBIMPHFluorinatedAnalog1;3-Fluoro-N-hydroxy-4-((2-methyl-1H-benzo[d]imidazol-1-yl)methyl)benzamide
ProductTypeChemical
Properties
FormulaC16H14FN3O2.HCl
MW299.3.36.5
PurityChemicals≥95%(HPLC)
AppearanceOff-whitesolid.
SolubilitySolubleinDMSO,ethanol,methanolorwater.
IdentityDeterminedby1H-NMR.
InChiKeyNWMOSGPUNITEFR-UHFFFAOYSA-N
ShippingandHandling
ShippingAMBIENT
ShortTermStorage+4°C
LongTermStorage-20°C
HandlingAdviceKeepcoolanddry.
Protectfromlight.
Use/StABIlityStableforatleast2yearsafterreceiptwhenstoredat-20°C.
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ProductSpecificationSheet
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  • Cellpermeable,potentandselectiveclassIIbHDAC6inhibitor(IC50=3nM).DisplayshighselectivityoverallotherHDACs(IC50=0.03-20µM).
  • Inducescellularα-tubulin,butnothistoneH3hyperacetylationinNeuro-2acells.Promotesmitochondrialtransport.
  • ShowsimprovedkineticsandbiochemicalpotencyagainstHDAC6comparedtotubastatinA(AG-CR1-3900).
  • HDAC6deacetylatestubulin,HSP90andthecorehistones(H2A,H2B,H3,H4).Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.HDAC6playsanimportantroleinmicrotubule-dependentcellmotility,transcriptionalregulation,degradationofmisfoldedproteinsandcellcycleandisinvolvedinautophagy,inflammation,cancerandneurodegeneration.
ProductReferences
  1. Bicyclic-cappedhistonedeacetylase6inhibitorswithimprovedactivityinamodelofaxonalcharcot-marie-toothdisease:S.Shen,etal.;ACSChemicalNeuroscience(submitted)(2015)