ProductSpecification:

AlternativeName:PNP14,Phosphoneuroprotein14,SNCB
 
Host:Rabbit
 
Immunogen:Syntheticpeptidecorrespondingtoaa97-111ofhumanβ-synuclein.
 
UniProtID:Q16143
 
Speciesreactivity:Human,Mouse,Rat
 
Applications:IHC,WB
 
BlockingPeptide:ForBlockingpeptideseeProd.No.BML-SP9345.
 
Formulation:Liquid.InPBS,pH7.4containing0.01Msodiumazide.
 
Handling:Avoidfreeze/thawcycles.
 
Shipping:ShippedonBlueIce
 
LongTermStorage:-20°C
 
ScientificBackground:β-synuclein(phosphoneuroprotein14;SNCB)isabundantinthecentralnervoussystemandislocalisedatnerveendingsbutnotinsynapticvesicles.β-synucleinisassociatedwithnovelaxonalpathologyinParkinson’sdiseaseandindementiawithLewybodies.Unlikea-synucleininwhichtwomutationsassociatedwithfamilialParkinsonsdiseasehavebeenfound,nopathogenicmutationshavebeenidentifiedinβ-synuclein.β-synucleinexpressioninthetestischangeswithdevelopmentalstage,beingincreasedmarkedlywhenspermatogoniaundergotworoundsofmeiosis,suggestingaroleforβ-synucleininmeiosis.