• Description
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  • References

Description

MonastrolisapyrimidinederivativeinhibitorofkinesinEg5thatinhibitsATPaseactivityandbipolarspindleformation.Monastrolexhibitsanticanceractivity,activatingthespindlecheckpointbutalsoinducingmitoticarrestandapoptosisinHeLacells.Monastrolalsoinducesdendritegrowthandaxonalshorteninginneurons.

ProductInfo

CasNo.

254753-54-3

Purity

≥95%

Formula

C14H16N2O3S

FormulaWt.

292.35

ChemicalName

1,2,3,4-Tetra-hydro-4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylicacidethylester

IUPACName

ethyl(4S)-4-(3-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate

MeltingPoint

184-186°C(lit.)

Solubility

SolubleinDMSO(100mg/mL).

Appearance

Whitetolightyellowsolid

ShippingandStorage

StoreTemp

4°C

ShipTemp

Ambient

Downloads

InfoSheet

M5752InfoSheetPDF

References

ChinGM,HerbstR.Inductionofapoptosisbymonastrol,aninhibitorofthemitotickinesinEg5,isindependentofthespindlecheckpoint.MolCancerTher.2006Oct;5(10):2580-91.PMID:17041103.

MaligaZ,MitchisonTJ.Small-moleculeandmutationalanalysisofallostericEg5inhibitionbymonastrol.BMCChemBiol.2006Feb27;6:2.PMID:16504166.

YoonSY,ChoiJE,HuhJW,etal.Monastrol,aselectiveinhibitorofthemitotickinesinEg5,inducesadistinctivegrowthprofileofdendritesandaxonsinprimarycorticalneuroncultures.CellMotilCytoskeleton.2005Apr;60(4):181-90.PMID:15751098.

MaligaZ,KapoorTM,MitchisonTJ.EvidencethatmonastrolisanallostericinhibitorofthemitotickinesinEg5.ChemBiol.2002Sep;9(9):989-96.PMID:12323373.